| Description | The human BRCA1, the product of breast and ovarian cancer gene 1, is a hyperphosphorylated protein functioning as a tumor suppressor involved in both transcription regulation and DNA repair. BRCA1 associates with RAD51 and has shown to be required for transcription-coupled repair of DNA damage as well as for the repair of chromosomal double-strand breaks (1-5). Association with a human SWI/SNF-related complex has recently suggested a potential role of BRCA1 in linking chromatin remodeling to breast cancer (6). Recombinant BRCA1 can be used for: 1) in vitro function studies including transcription and DNA repair; 2) protein-protein interaction assay; and 3) cell growth assay. |
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