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PKACA (Protein Kinase A Catalytic subunit alpha)

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Description:

Protein Kinase A Catalytic subunit alpha (PKACA)(Cat# P5013)

Species	Human
Expression Host	E.coli
Tag	No tag
Purity	95%
Molecular Weight	40.5 kDa.
Gene Accession Number	NM_002730.

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SKU	Price
P5013	$283.80

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Description	PKA Cα, cAMP-dependent protein kinase catalytic subunit alpha, is involved in regulating cellular functions as metabolism, ion transport, and gene transcription. Free catalytic subunits of PKA can phosphorylate a wide variety of intracellular target proteins, such as NF-γB, NFAT5, CREB, GSK3α, etc. Mutation of the PKA Cα in mice leads to growth retardation and sperm dysfunction. Anti-PKA Cα autoantibodies are biomarkers for cancer diagnostic.
Synonym	cAMP-dependent protein kinase catalytic subunit alpha isoform 1; MGC102831; MGC48865 and PKACA.
Sequence	MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WESPAQNTAH LDQFERIKTL GTGSFGRVML VKHKETGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFSE F
Formulation and Storage	Suppplied in 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA. This Product is stable at -70°C for at least 6 months from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.
Application	PKA C alpha is active and can be used in kinase assay. It is also a good biomarker for cancer diagnosis. For research use only.
Reference	1. Tasken, K. et al. (1996) Genomics 36:535. 2. Skalhegg, B. S. et al (2002) Molec. Endocr. 16:630.
SDS-PAGE stains with coomassie Blue and Western-blot

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