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MEK3 |
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Description:Gene Access number is NM_145109. Gene synonym include MAPKK3; MEK3; MKK3; PRKMK3 and Homo sapiens mitogen-activated protein kinase kinase 3 (MAP2K3). Recombinant MEK3 was expressed and purified from bacterial system. p5059-01 contains 10,000U in 33ul.View Full Specifications |
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This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. |
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