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Cyclophilin A (100 ug) |
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Description:Recombinant Cyclophilin A protein, 6His-tagged, expressed in E. coli and purified by an affinity column in combination with FPLC chromatography. Gene access number is NM_021130. Gene synonym include CYPA; CYPH; MGC117158; MGC12404; MGC23397 and peptidylprolyl isomerase A. p2043-02 contains 100 micrograms.View Full Specifications |
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Cyclophilins catalyze the isomerization of peptide bonds from trans form to cis form at proline residues and facilitate protein folding.
Human cyclophilin A forms a dimer, and inhibits the calcium/calmodulin-dependent phosphatase calcineurin. This inhibition is thought to suppress organ rejection by halting the production of the pro-inflammatory molecules TNF alpha and interleukin 2. Cyclophilin A is one of the cellular proteins that gets incorporated into budding HIV particles and may be important for HIV assembly and infectivity. |
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