TRANSCRIPTION FACTOR II B

Admin • Jan 07, 2015

Tubon et al., "Nonconserved Surface of the TFIIB Zinc Ribbon Domain Plays a Direct Role in RNA Polymerase II Recruitment", Molecular and Cellular Biology, 24:2863-2874, April 2004

Transcription factor IIB (TFIIB) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is encoded by the TFIIB gene. Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between transcription factor IID, which initially recognizes the promoter sequence, and RNA polymerase II. It is involved in the selection of the transcription start site; mutations in TFIIB cause a shift in the transcription start site.

Interactions

Transcription factor IIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID, and the RPB1 subunit of RNA polymerase II.

Transcription Factor IIB makes sequence-specific protein-DNA interactions with the B recognition element (BRE), a promoter element flanking the TATA element. The role of TFIIB in the vast number of human promoters lacking TATA and BRE elements remains unclear.

Recent study shows that TFIIB links transcription inhibition with the p53-dependent DNA damage response.

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